IMHO, go to the range to test lowest, reliable, accurate load, at that range, beginning with about 20-25 gr and work down from there.hELLO , WE HAVE A SQUIRREL PROBLEM AND I WOULD LIKE YOUR RECOMENDATION FOR A MINIMUM .45 LOAD TO KEEP NOISE AT THE LOWEST LEVEL. ABOUT 25 YDS WILL BE THE SHOOTING DISTANCE. tHANKS, SHAGBARK