Since moving here I have taken 198 deer with revolvers. Modern and BP. My last with the Ruger OA went over my fence and hit the ground dead. Distance she went was 6' straight up.
Velocity is not needed and makes things worse. The best for a fast kill is my OA .44, .45 Colt and .475 with heavy bullets. As soon as I make a flat nose too fast I will lose deer. Even with two holes I find no blood trails. velocities range from 1100, 1300 and 1350 FPS. Moving to the 45-70 revolver and I get a hole and if I recover the deer hit at 1632 FPS, lungs are still pink with a hole only. I am convinced the pressure wave will move tissue out of the way. You MUST leave energy inside the animal. BP guns are super at doing it. A RB leaves nothing to be desired. I killed many deer with a .45 flintlock in Ohio and PA but once I killed a deer on a full out leaping run at 125 yards with a .50 TC and a Maxi ball. I swung way ahead and a foot high for double lungs.
Going larger to the .500 JRH and a 440 gr bullet at 1350 FPS gives me trouble with deer going 120 yards with no blood on the ground. I shot a doe and lost her, then a buck came out at about 120 yards and I hit him. He ran to me before dropping. I back tracked and there was no blood on the ground at all. I was gutting and it got dark, when I flashed my light I seen white up the hill to find the doe at least 100 yards from where hit. I had spent 3 hours trying to find her. I back track every deer and do a necropsy on every one to see what the ball or bullet did.
I grit my teeth when a guy wants 1500 FPS from a .44 with a light bullet. ME is a myth and a RB with BP is much better.