I have several rifles in .50 and .54 cal with 1:48" twist rifling. All are tack drivers relative to the shooting I do. In fact, at the last trip to the range, I spent part of the day shooting at grapefruit sized balloons at the 100 yard berm. Occasionally I missed. It really upset another shooter who was dialing in his scoped hunting rifle, since I was just standing there plinking balloons with my .54 cal flintlock ... Lyman Deerstalker.
Apparently Mr. spendy rifle knew enough about black powder to be able to tell that the short barrel with an attached flint wasn't supposed to be that accurate. He could hit a balloon, too, but it took him 3 shots, even from a bench rest. I asked him if he planned to hunt deer from a bench, or if he could stand up and hit something. There were still 3 balloons standing when I left.
I do have a 1:60" rifle, and I can get better velocity with it, but accuracy isn't perceptibly better or worse than with my 1:48" barrels. On paper, any of the rifles are capable of one big raggedy hole in the center of the paper - if I take the time and pay attention.
You didn't mentioned if you were gonna build a rifle. If so, you may want to pay attention to all the hoopla about rifling depth, twist rate, and custom barrels.
Otherwise, if you just plan on buying your first rifle, take a look at what's on sale at the Forum Classified Ads. There are a bunch of 1:48" rifles, and also a 1:60" there, many at reasonable prices, and any of which will get you familiar with running a muzzleloader. And any of them will give you enough accuracy to keep up your interest while not draining your wallet. If you decide you like it, you will also get a better idea of what you want next, and there's where all this BS about custom barrel configurations begins to matter. Until then, get something - cheaper is better, and get out and make the most of the capability of your purchase. You'll discover that it is likely more capable of accuracy than you are. As you hone your skills, that may change, and you may someday grow to want something "better".
I was surprised at the accuracy of my Deerstalker Flint - from all the talk by those in-the-know, it's not supposed to be more than a utilitarian hunting rifle, and marginal at that. Apparently they spend more time talking than shooting.
Buy something cheap, and go shoot it. It needs dialing in to your preferences, so concentrate on first developing an accurate load. You can tune it more, later, by varying patch thickness to find optimum consistency in groups on paper.
You will be able to spend the rest of your life listening to all the tales about how much better a particular bullet lube is than another, but in general, anything of the classic tallow + beeswax, beeswax and olive oil or even spit, if you have enough, will work well. Concentrate on sight picture and rifle skills, and let the keyboard-types try to sell you on spiffy nipples, or a particular brand of caps. It really doesn't matter - at least not yet.
If you take your time, you can make just about any rifle perform to your expectations. The Mountain Men didn't have the luxury of whining about their barrel not working, or patch lube isn't any good. They either made what they had work, or starved.
You're not only not gonna starve, but if you have any modern rifles, you'll find you will be spending much less quality time with them, and more time burning black powder.
So. look here first:
http://www.muzzleloadingforum.com/pp-classifieds/showcat.php/cat/9
From around $150 to $400, they're all fine choices to get you started.
Whether .45,.50 or .54 caliber, all are capable if fine accuracy, and anyone shooting any of them will tell you about it.