that's a somewhat open ended question. the short answer is it depends on your rifle, and the conical! i have a cva kentucky in .45 cal. that shoots 255 gr. lee round nosed, flat point handgun bullets (cast in pure lead, of course!) almost as well as it shoots plain round balls! i have considered getting the 300 grain gas check mold and trying it out, but it's questionable if it will shoot. the nice thing is lee molds are cheap, so if it doesn't work, there's not much loss! just for reference, the cva has a 1-in-66 twist.