As mentioned above, work up a load that will group well first. For example, hold your sight directly on the bull for every shot. Once you find a load that produces groups you like, then you can start adjusting sights to move the group to where you want it to be. Typically you will have the groups print just above the front sight but that's up to you. Then, use that load all the time,knowing that if you change a component or charge weight, your groups may change drastically.