I practice out to 200yds at the range, and out to whatever range is available to me on private land when friends allow it. This includes some shooting out to 1200 yds in the past, so I know some shooters can do some amazing shooting with irons, since I used to be able to keep 9/10 rds on a human silhouette at 1k with irons, but I won't take shots at over 125 yds (and prefer much closer) with anything firing PRB due to the way the RB slows and drops at those ranges. I'd say practice out to as far as you possibly can, but limit shots to 100yds or maybe slightly over if perfect conditions present themselves. It isn't anything against you or any of us, just a matter of the ballistic characteristics of a RB, no matter how fast you choose to try and drive it. The good news is that the same lousy aerodynamics that limit range also help anchor the animal once you hit flesh, so it's a double edged sword. You can take longer shots with conicals, IF you know the exact range and know the exact drop you will get at that exact range, but it will take a lot more lead, powder, and pain in your shoulder. Some choose to put up with it the extra cost and pain, while the rest of us just sneak in a little closer and enjoy more range time. Another advantage is it is easier to clean a PRB gun since cloth doesn't leave leading for you to have to clean out. Here is my take on it, and worth every penny you paid for it. If I was wanting a long range competition rifle where I was shooting at 500 to over 1K yards, I would go with a conical bullet and a barrel appropriate to it, but since you specifically said this is for hunting, I would stick with a PRB and not even consider the conical and the extra costs and trouble it presents because it just isn't the least bit necessary within the ranges you mentioned. Here is my thinking as far as range goes, if you can get inside 150, then you can get inside 100-125, after all, what's another 25-50yds closer to your target. You may have to pass on a few shots, but will easily be within range for the vast majority of them. The lower cost of shooting PRBs will allow you to shoot more and be a better shot, in addition to the satisfaction of doing things the old traditional way and being successful. Like others have said, a PRB works very well, in fact, much better than people who haven't used it would believe.