The rate of twist required to adequately stabilize a bullet in flight is largely dependent upon its length and to a lesser degree, its velocity. However, at muzzleloader velocities it's not a concern. So, back to length. For any given caliber, the longer the bullet the heavier it is. Therefore, the faster those long/heavy bullets have to be spun in order to be gyroscopically stable in flight. Your opening post mentioned a .50 caliber. The lightest .50 caliber conical that I'm aware of is the 250gr. Lee R.E.A.L. Is the 1:60-something twist you mentioned having fast enough - maybe, I don't know. My gut feel is probably not but if you wanted to try, I'd recommend a heavy charge of powder in order to get the velocity up as high as you safely could. Will a 1:24 twist stabilize that bullet, sure. Is that rate of twist required, my guess is no. I bet a 1:48 would work just fine. The other end of the spectrum is the 395gr. Plains bullet. There may be heavier ones out there but that is the heaviest one I could think of off the top of my head that I have experience with. I will say this, I couldn't get that Plains bullet to shoot well out of a 1:48 barrel, no matter how fast I drove it. So, its 1:24 for me. I might have to play around with the powder granulation and/or charge, but if I can get a bullet down the barrel, I'm willing to bet I can get it to shoot pretty well.
I like to hunt so if I'm going to shoot a critter with a bullet, I like to shoot the heaviest for caliber bullet that I can get to shoot accurately. Heavier bullets have higher sectional density (the ratio of bullet weight to the square of its diameter) which means better penetration, everything else being equal. Better penetration can mean the difference between just one hole in and one hole in and one hole out. Two holes means more air in and more blood out.
I didn't bother to repeat the answer that
@Grenadier1758 posted earlier regarding what GPH stands for.
Hopefully this helps...