Yeah, it's "what I do and enjoy". I tune SA revolvers, mostly open-top platform but Remington and Ruger ( 3-screw) as well.
I've got 5 Rugers (ROA's) with Kirst conversion cylinders (all American made). They can handle extreme loads (well, not quite sure about the one "fixed sighted" SS version yet but it's the equal to the original Vaquero) . . .
Much of the conversion "interest" is because it's historical, Colt did it, Remington did it so I do it but all of my examples are made of much more modern materials than the originals. That allows me to take a modern "path". Since I have to shoot at indoor ranges, it has to be smokeless, so conversions allow me to still shoot MY favorite revolvers.
Well, the "designers" would have to have known the future for that to be true . . . the revolvers were designed to work with what they had ( not to mention it was fairly new "ground " still. They had no idea how far their design could go!). Just as the original SAA can't handle smokeless rounds, the modern copies can be had in modern mag. calibers.
So, what is being learned in my instance is where the limits actually are for the modern open-top revolver. The tensile strength of the arbor in a belt pistol is in the 50K psi range, the horse pistols are a bit more.
So, it's not a "materials" thing, it's not a "design" thing, it's definitely not an "inadequate cylinder" thing. It's actually the "build quality / fit" that is the limiting factor for the open-top platform. I'm already in the +p range with 2 loadings.
My ROA's can do the same as your Ruger Bisely . . .
Mike