What everyone has mentioned is good, but lets backup a bit. First you mentioned a .50 cal. flintlock. second, what powder, patch and ball size are you using. third what is the barrel twist. You need a good tight, well lubed patch/ball combo. For .50 cal. 1 in 66 is best, while 1 in 48 is ok and needs some work to fine tune your loading. If you are not using real black powder you will have trouble with fast ignition if at all with some of the subs. Your best bet is to start at 25 yards, like has been said, and benched. With a .50 start at 60 grains of FFFG, or 70 of FFG. Shoot three to five shot groups, and the tightest patch/ball combo you can load. .490, with an 18/20 thou. patch may work, but a .395 with a .12 to 15 thousandths may be better. Its all a matter of trial and error, and each gun is different. Another thought is to mic. the barrel to see what your 50's bore really is, in order to give you a starting point.
Bill