What do you hunt? I think that makes a big difference in recommending something.
I agree with others that a .40 or .45 makes a very sweet rifle, but if you hunt elk or black bear those wouldn't be the best choice.
For easy-on-the-shoulder, large flatter butt plates make a big difference in distributing recoil. To reduce carrying weight an A or B weight swamped barrel (depending on caliber) or a tapered Octagon to Round rifled would be great.
I have an "Early Virginia" with a 44" Green Mountain swamped barrel in .54 cal that comes in at under 8# and balances like a dream. Anyone who picks it up immediately comments on how great it shoulders and points. It was made by Larry Williams.
The flat butt plate and "dainty" build characteristics are, in my opinion, two of the secrets to great handling and comfortable rifle. Too light, though, and a lot of recoil can be transferred to your shoulder. This one seems to be in the sweet spot for me.
PS: My Hawken is still a great favorite of mine, but at 10 1/2# and with the skinny curved buttplate, it isn't really nice to carry around nor shoot long days at the range. Just somethin' about a Hawken though!