The first rule of gunfighting is always have a gun.
The second rule of gunfighting is, he who has the most rounds usually wins.
I kept an original 1860 army Colt for home defense, back in the day, when that was all I had. I graduated to a modern revolver in the 70's. A 1911 in the 80s and 90s. I now carry a high cap semi auto for serious use.
Remember a 36 cal percussion revolver is roughly equivalent to the old underpowered 38 S&W. the Army 44 is roughly equivalent to a low powered 44 special and I wouldn't trust either one of those rounds to save my life or the lives of my wife, children, and grand children.
IMHO, the slow operation of a single action revolver can't compete with a punk armed with anything modern. Nor can one change cylinders in the dark, under intense pressure of a lethal force situation as quickly as a punk can swap a modern mag in a modern bottom feeder.
Not to mention that replacement cylinders need to be timed to the action of the pawl and cylinder lock to work properly to align each chamber with the barrel.
The real question is one of parity? Equality of weapons of offense and personal defense, if you will? IMHO, a single action percussion revolver just can't stack up to even a double action revolver, antique or otherwise. Nor can a BP revolver stack up to anything more modern where speed, accuracy, ease of use, and reliability are paramount to saving ones life, not to mention the lives of loved ones.
Then there is the question of multiple attackers?
Can you keep BP revolvers operating well enough to fend off two, three, or more attackers in a dark home, under intense pressure?
Zonie, I apologize for mentioning modern alternatives for self protection. However this topic cannot be discussed without mention of modern alternatives.
God bless
J.D.