Yep. I'm going to start at 60gr 3F (cause I don't have any 2F) and go from there as I'll be punching more paper than anything else. I used 6 pumps on my primer. Seems a little excessive, but the pan on that lock is huge.
So long as you don't cover up the flash hole you shouldn't see any slow down in lock speed. The mushroom cloud coming off the lock will be impressive too! Like your own little Bikini Atoll!