Well, not to state the obvious but the barrel itself ought to be okay, the issue is if the drum blows out or the two blind holes blow out.
I'd would do a several test firings. First with a PRB and normal load- see how that works. A heavy bullet causes higher internl pressure so instead of two PRB maybe a conical and normal charge. Then the PRB but with a double charge.
Dixie shows a gun in a spare tire- that would be a pretty good way to test.
There is also the issue of escaping gases. The barrel and drum may stay tight but put some leather or similar object in the path of any escaping gases- just to make sure you don't get a bad burn.
I would never throw out a barrel. You can always cut off the breech a couple of inches and re-thread in a new breech plug and try again. You can also use them for a couple of pistol barrels.
I, and a lot of other folks on this forum, are always looking for stock for future projects. Don't toss the barrel.
And....check out Dixie Gun Works and TOW, I think I recall breech plugs that have a patent breech/nipple type arrangement- not hooked but you are good to go with the new plug- in case you screw up.
Let us know what you did and how it worked. Good luck.