200 rounds with that cylinder certainly provides a data point, but you'll need to see how it does after a few thousand rounds for more data. In fact, I would do examinations of the weapon after every 500 rounds to look for changes indicating wear from the centerfire ammo.
With that being said, though, 21,000 PSI isn't really a high pressure. 38,000 and higher is where your Magnum calibers run, and plenty of top strap designs have proven themselves able to stand up to thousands of high-pressure rounds.
I really would be interested to see how many rounds your setup will run before you need to do work on the arbor or another part subject to pressure. It would be a good experiment to run and lots of fun.
I'll volunteer if you need someone to help you with the shooting, too. I wouldn't want you to wear out your hands with all of that reloading and shooting. I'm more than happy to help contribute to your scientific research efforts.