TDM is spot on. I love the search function on this site. With a simple search, you get all the information that has gone before. Billy C, go up to the top right of screen and enter in the search domain: loads for .50. You will come up with an encyclopaedia of responses that you can go through at your leisure - your answer is hiding in there.
Just to help, a buddy hunts with a .50, deer, pigs, wild dogs and such. After a series of trials, he finds he likes patched roundballs out to 50 metres, 65 max. His load for his Pedersoli Tryon is 60gns FFG real black, a .018 pillow ticking spit lubricated patch and a .495 ball, set off with RWS ignition cap. He is a cautious hunter, enjoys the stalk and getting right in the target's loungeroom; his results are humane, and he always seems to fill the fridge. Mind, you have bigger stuff over there, and will have to adjust to your target species accordingly.
As to that heavier load raising the POI, that's best for you to sort out at the range with your particular rifle, settled down behind a good rest and some eight-inch black circles ...
Oh, and get to know your target species anatomy. Every beast has a heart and lungs, but each species lies in a range of combinations, some forward, some back, some higher, some lower.
Cheers, Pete