Take a look at this link to Dixie Gunworks New Model Remington Pocket pistol.
http://www.dixiegunworks.com/product_info.php?products_id=898
Is this the gun we are speaking of?
I suppose it's possible for the frame to get stretched or battered but I'm not sure how someone would go about doing that.
The small powder charge, even if maxed out shouldn't damage the frame.
Apparently the Remington company agreed with this because this is the only revolver model that Remington actually offered with a brass frame back in the 1860's.
With the larger brass framed Remingtons clones made in Italy the usual damage from hot powder loads is at the rear of the cylinder.
When the gun if fired the cylinder recoils hard against the brass frame at the rear and repeated firings can cause the brass in that area to deform.
If this happens the cylinder will move forward and aft more than it is supposed to.
I suppose if it got bad enough when the gun fired its cylinder would move back and slam into the frame at the back.
The impact of that happening could conceivably jar some unfired caps loose from the nipples.
If a loaded chamber doesn't have a cap on its nipple it can chain fire.
By the way, if I push the cylinder back away from the barrel on my Remington Pocket pistol the gap between the front of the cylinder and the rear of the barrel is about .015 (1/64) of an inch.