I started with Pyrodex in my first muzzle loader, a CVA percussion rifle. I continued to use it in my revolver, percussion pistol, flintlock and inline, because it was easy to get. And what I noticed was every time I pulled the trigger on any of those guns they all went 'KA-POW'. And little round holes appeared in the target (whether paper or something else)...every time.
Then I went to a local BP club meeting/ shoot and was LECTURED on how much better real BP is...
So I tried it...and it went 'KA-POW' too! And little round holes appeared In the target (whether paper or something else) just like they did when I used Pyrodex. Imagine that.
When I'm at the range I clean/swab the bore after X-number of rounds fired. Since I'm never in a hurry at the range, cleaning the bore using powder type X-Y or Z was/is never an issue. I've never found one type of powder so hard to clean out that I threw my hands up in disgust and cursed the Gods of Black Powder for tricking me into using such a terrible product.
When I deer hunt with my flintlock or inline I do my part by making the gun go 'KA-POW' just once, and the deer do their part by falling down dead right away. So, cleaning is easy.
Ironically, I just got home from the local PEW-PEW store, that happens to sell BP and BP substitutes, and the sales guy said he and his distributors are out of Swiss 3F. And his prices on Pyrodex are high-ish. So I bought some GOEX 3F (it was $4.00 cheaper).
The morale of my story is, in my opinion, use what you like, or what you can get.