Here's some more poppy cock for you.
Regulating double rifles is a mixture of ballistics, experience, and mysticism, and a long-standing one. There are several approaches, but the intent is to get the barrels to shoot very close to point of aim, to each other and over a usable variety of ranges. The whole point of the double rifle is to provide a quick second shot, at the expense of perfect accuracy.
There are a variety of approaches for doing this, but a combination can be used as well. Krieghoff's primary approach is based on a muzzle clamp that is adjusted at the until a high degree of consistency is achieved for a standard recommended load.
Rigby (the California Rigby) uses a muzzle clamp, and then soldiers the barrels in place once the desired result is achieved.
Pedersoli bore sights the barrels using a laser and then soldiers the barrels. Finer adjustments are made at the range by filing the muzzle (s). Since this is done in Italy the standard is metrical, but 75 yards would be a rough approximation. The double leaf sights are higher and lower to adapt for the longer and shorter range. How well regulated are they? Richard Beauchamp says "pretty well." The laser bore sighting should help a lot. They can't be getting the attention of a custom double rifle, but the Pedersoli Kodiaks are fired by a live person at their range. With a muzzle loader the end-user variables are, uh, considerable (we aren't accurately matching batches of powder, loading compression, ambient temperature, or perhaps, projectiles).
Dietrich Appel, who was my gunsmith until he retired, did a lot of custom regulating of double rifles, combination guns, and drillings (all cartridge as far as I know). It was the one thing he did not delegate at all.