A possible variant might be related to breaking the sound barrier. A round ball is not the most ballistically effective design and encounters significant bow wave issues when breaking the barrier. Shooting velocities that break the sound barrier could happen at different points along the trajectory, depending on the velocity of the load. It could possibly affect POI. That being said, most of us probably can't out shoot the result. My .50 caliber flintlock shoots very accurately with loads ranging from 65 to 110 grains of 2FF. Seventy five grains of 2FF produces the tightest groups most consistently. The search for the "sweet spot" is half the fun.