It totally depends on your accuracy vs. range. My .54 flintlock is pushing the ball 1734 FPS MV. I have good sights and good vision. Off the bench, I can get 2.5-inch and sometimes smaller 5-shot groups at 100-yards. I practice on a life-sized deer or antelope target from the standing, sitting and prone position (standing and sitting using sticks). I can keep my shots under these circumstances within the animals vital zone at 100-yards consistently and repeatedly. I shoot in the wind and use a wind-meter and I shoot to 150-yards. I feel I know the rifle's accuracy, my capability and how to figure drop and windage out to 150-yards. I do not feel comfortable shooting an animal at 150-yards as a routine. However, with a totally steady kneeling rest off sticks with light wind, I did shoot an antelope at 137-yards. On other occasions, I have shot whitetail deer at 100 - 110-yards with a rest or sticks. I've taken two elk that coincidentally were both 80-yards. After these accomplishments, I have decided to keep my maximum range to 120-yards under ideal circumstances on game animals. The real drop at 150-yards with a 100-yard zero is 20-inches. That means holding off the animal quite a bit. The wind at 10 MPH at 100-yards moves the ball 4-inches. 20-MPH moves it about 8-inches. That's too much already to be shooting further and trying to compensate, in my opinion. I think the question is, "At what range can you keep your shots in an animals vitals considering the wind" ? When considering Coyote, the vital size is going to be somewhat smaller than a deer and I think it deserves the same respect for life to make shots that you know will hit vitals. The range may be less or the same as for deer, but I don't think it should be longer.