Yes, use 2 PRB's. I did shoot several times with the same charge as a single PRB and did well, slight drop in POI. I started exiperimenting and found that a drop in powder charge resulted in more drop but tighter pattern, I figured it's worth the loss in velocity. Your rifle probably may shoot different, I have 24" barrel, 1-48 twist. This is where I found out that an over-powder felt wad makes a difference in accuracy, when testing using this load. Before I did not use one. I found out that it tightens groups with either 1 or 2 PRB's.
I practice off-hand at 30 yds. and shoot off a rest at 50 (shoots well and consistent POI at that range). Have fired several shots at 100 but have to set my sights different than 50. When adjusted for 100 the shot is on a paper plate with the 2 RB's 4-6 in. apart. If I was hunting at that range I would not hesitate to take a shot if I had a good target and if I was sighted in for 100. Particularly if I had a rest to shoot from.
I have used 100 gr. and at 50 yds accuracy was fair but groups opened up, consistently hit 6" circle at this range, I got good accuracy with a single PRB and 80 gr. 70 is what I use with a double PRB.
I plan on getting a Lee REAL bullet mold to expiriment with and if it does away with 'drop' I probably will use them if I get as good group as PRB with more powder.