I don't shoot a .50, don't shoot a .54 very much. When I do my load varies between 80 and 110 grains of 3F, depending on where I'm hunting. At home in Kentucky it's 80, because the shots are closer and I'm more likely to be able to pick a good POI. When I've been able to travel to the west to hunt it has been 110, since I plan for shots out to 125+ yards. These discussions always seem to revolve around killing power, but that's something I've never worried about. It doesn't take much power to kill a whitetail. Still, I tend to use heavier charges, because they flatten the trajectory a bit, which extends my range and makes hitting the spot a little easier. I always plan for the longer, tougher shots, then avoid them like the plague.
I use the 'point blank range' method for hunting, so the trajectory is the thing.
Recoil isn't a problem for me. My guns tend to be heavier, which minimizes it, and I'm pretty tolerant of what there is.
Spence