The reason bang says that, is not to seal the chamber, it is that a larger diameter ball, will provide a longer bearing surface for more contact with the rifling as the ball goes down the barrel, making less chance for it to "skip" across the grooves and impair accuracy, a possible effect of heavier, higher velocity charges. Wonder Wads won't help this, if it becomes a problem. nkbj's use of bullets follows this same line of thinking.
A side affect of using the .457 ball though, is going to be the difficulty of loading and the additional stress and strain on the loading lever if you load with the cylinder on the gun (if you load the cylinder in a stand off the gun, no problem) It is a solution I would keep in my pocket if you experience poor accuracy and or leading with the smaller diameter ball.
As far as powerful vs safe, any handgun is going to last longer and stay in better shape suing lighter loads. Case in point are the magnum revolvers, feed them a steady diet of top end loads and they will get loose, same with the Walker. I have no doubt 60 grains is safe, but I also have no doubt that top end loads like that will wear it faster. I have a S&W 29 that as a back up for hunting dangerous game I use a 300 gr HP over a stiff charge. For plinking or competition I use a light 240 grain LSWC.44 Special loading, as I have no doubt the 300 grainers are going to beat on it.
Its like owning a fast car and not driving it to the limit all the time, to save on repair bills, but knowing the power is there if and when you need it.